Product development and storage

Research leaders

Associate Professor Denese C Marks
A/Prof Denese C. Marks

Research Program Leader

Product Development and Storage Research Group

doctor lacey johnson
Dr Lacey Johnson

Principal Research Fellow

Product Development and Storage Research Group

Doctor Lauren Waters
Dr Lauren Waters

Postdoctoral Research Fellow

Product Development and Storage Research Group

Current projects

 

Keeping an eye on quality 

In addition to our routine quality assays, our researchers are regularly using other state-of-the-art measurements to test red cells, platelets and plasma products at all our manufacturing sites. This testing allows us to monitor the effects of changing blood collection or manufacturing processes. 


 
Donation frequency and red cell storage 

During storage, red cells sometimes become more fragile, causing damage that may be detrimental during transfusion. We’ve compared storage of red cells from frequent donors to red cells from less frequent donors to find out whether iron deficiency plays a part. We found the opposite to what we expected: red cells from donors with high iron levels may not store as well as those from “average” donors. 

 

Better outcomes for premature babies 

Almost 90% of babies who are born at less than 29 weeks gestation will need a transfusion of red blood cells. The challenge for their doctors is to make sure that transfusions don’t cause extra problems for the already fragile immune systems of Australia’s tiniest patients. 

A pilot study, working with researchers from the Women's and Children's Hospital in Adelaide, showed us that babies who received a transfusion of washed red cells had lower inflammatory responses after their transfusions. 

We’re now moving on to a larger study supported by the National Health and Medical Research Council, to be conducted in hospitals in South Australia and NSW.  
 

Testing times for frozen blood 

We’re a vital part of a $1.8 million research study into the safe use of frozen blood platelets that could revolutionise the way blood is used in the treatment of critical care patients. 

Platelets are the component of blood that helps it clot, and when stored at room temperature, they have a short shelf-life of five days. With this short shelf-life, it’s difficult for many small rural and remote hospitals to keep enough platelets in stock. If we could successfully freeze and thaw platelets, we may be able to extend this storage time up to two years or more.  

In collaboration with Professor Michael Reade (Chair of Military Medicine and Surgery at the University of Queensland) our researchers are preparing for a large clinical trial known as CLIP-II, which will test the use of frozen platelets in cardiac surgery patients. 

We hope that the study, which is planned to take four years, will lead to frozen platelets being registered by the Therapeutic Goods Administration for widespread use, and improve the supply of platelets for Australians in remote areas.

Selected publications

Freezing expired platelets does not compromise in vitro quality: An opportunity to maximize inventory potential
Johnson L, Waters L, Green SM, Wood B, Marks DC
2020
Transfusion
60: 454-459
Not all red cell concentrate units are equivalent: international survey of processing and in vitro quality data
Shih AW, Apelseth TO, Cardigan R, Marks DC, Bégué S, Greinacher A, de Korte D, Seltsam A, Shaz BH, Wikman A, Barty RL, Heddle NM, Acker JP
2019
Vox Sang
114: 783-794
Serum growth factor stability in different eye drop packaging systems during storage
Tan JCG, Webb RG, Marks DC
2020
Transfusion and apheresis science
59: 102608
The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation
van der Wal DE, Davis AM, Mach M, Marks DC
2019
Haematologica
215830
Calcium chelation: a novel approach to reduce cryopreservation-induced damage to frozen platelets
Waters L, Padula MP, Marks DC, Johnson L.
2020
Transfusion
10.1111/trf.15799