Cryoprecipitate is prepared from plasma derived from both whole blood and apheresis donations. Fresh frozen plasma (FFP) is slowly thawed at a temperature between 1–6 ˚C and the resulting cold-insoluble products are recovered and then refrozen.
One unit of apheresis cryoprecipitate is approximately equivalent to 2 units of whole blood-derived cryoprecipitate.
Cryoprecipitate contains most of the factor VIII, fibrinogen, factor XIII, von Willebrand factor and fibronectin found in FFP.
Cryoprecipitate has a shelf life of 12 months when stored at –25º C or below.
Typical unit content and specifications
The typical unit content data is derived from Lifeblood process control testing. For each parameter, the mean value (± 1 SD) and specification is shown.
Unless otherwise specified, data is for the period 1 January to 31 December 2020.
Cryoprecipitate whole blood
|Volume (mL)||36 ± 2 (30–40)|
|Factor VIIIc (IU/unit)||161 ± 33 (> 70)|
|Fibrinogen (mg/unit)||380 ± 114 (> 140)|
|Von Willebrand factor (IU/unit)||260 ± 51 (≥ 100)|
|Volume (mL)||60 ± 2 (54–66)|
|Factor VIIIc (IU/unit)||436 ± 70 (> 70)|
|Fibrinogen (mg/unit)||1067 ± 308 (> 140)|
|Von Willebrand factor (IU/unit)||732 ± 151 (≥ 100)|
Cryoprecipitate is available in all ABO groups. Matching for RhD group is not required.
There are no modifications available for cryoprecipitate.