Cryoprecipitate

Cryoprecipitate is prepared from plasma derived from both whole blood and apheresis donations. Fresh frozen plasma (FFP) is slowly thawed at a temperature between 1–6 ˚C and the resulting cold-insoluble products are recovered and then refrozen.

One unit of apheresis cryoprecipitate is approximately equivalent to 2 units of whole blood-derived cryoprecipitate.

Cryoprecipitate contains most of the factor VIII, fibrinogen, factor XIII, von Willebrand factor and fibronectin found in FFP.

Cryoprecipitate has a shelf life of 12 months when stored at –25º C or below.  

 

Typical unit content and specifications

The typical unit content data is derived from Lifeblood process control testing. For each parameter, the mean value (± 1 SD) and specification is shown.

Unless otherwise specified, data is for the period 1 January to 31 December 2020.

 

Cryoprecipitate whole blood

Volume (mL) 36 ± 2 (30–40)
Factor VIIIc (IU/unit) 161 ± 33 (> 70)
Fibrinogen (mg/unit) 380 ± 114 (> 140)
Von Willebrand factor (IU/unit) 260 ± 51 (≥ 100)

 

Cryoprecipitate apheresis

Volume (mL) 60 ± 2 (54–66)
Factor VIIIc (IU/unit) 436 ± 70 (> 70)
Fibrinogen (mg/unit) 1067 ± 308 (> 140)
Von Willebrand factor (IU/unit) 732 ± 151 (≥ 100)

 

Availability

Cryoprecipitate is available in all ABO groups. Matching for RhD group is not required. 
  

Modifications

There are no modifications available for cryoprecipitate. 

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