Additives and anticoagulants

Anticoagulant for whole blood collections

CPD (citrate phosphate dextrose)

Macopharma

66.5 mL of CPD anticoagulant is used per pack of whole blood.

Constituents	g/L	Total per pack (g)
Sodium citrate dihydrate	26.3	1.75
Citric acid monohydrate	3.27	0.22
Monobasic sodium phosphate dihydrate	2.51	0.17
Dextrose monohydrate	25.5	1.70

Anticoagulant for plasmapheresis collections

4% sodium citrate

Haemonetics Corporation

250mL mixed ~ 1:16 with whole blood

Constituents	g/L
Sodium citrate dihydrate	40

Anticoagulant for plateletpheresis collections

ACD-A (acid citrate dextrose)

Terumo BCT

750mL mixed ~ 1:11 with whole blood

Constituents	g/L
Dextrose monhydrate	24.5
Sodium citrate dihydrate	22.0
Citric acid monohydrate	8.0

Red cell additive solution

SAGM (saline adenine glucose mannitol)

Macopharma

105 mL of SAGM is used as the additive solution for resuspension of standard red cell components.

Constituents	g/L	Total per pack (g)
Sodium chloride	8.77	0.92
Adenine	0.169	0.02
Dextrose monohydrate	9.0	0.95
Mannitol	5.25	0.55

Washed red cells additive solution

SAGM (saline adenine glucose mannitol)

Macopharma

250 mL of SAGM is for washing of red cells. 100 mL of SAGM is used as the additive solution for resuspension of washed red cells, red cells for IUT and thawed frozen red cells.

Constituents	g/L	Total per pack (g)
Sodium chloride	8.77	0.877
Adenine	0.169	0.03
Dextrose monohydrate	8.18	0.818
Mannitol	5.25	0.525

Platelet additive solution (PAS)

SSP+*

Macopharma

The volume of platelet additive solution contained in each unit of Platelets Pooled in SSP+ is approximately 70% of total component volume.

The volume of platelet additive solution contained in each unit of Platelets Apheresis in PAS-E Leucocyte Depleted is approximately 60% of the total component volume.

Constituents	mg/100mL
Sodium chloride	405
Sodium acetate trihydrate	442
Sodium citrate dihydrate	318
Sodium dihydrogenophosphate	105
Di-sodium hydrogenophosphate	305
Potassium chloride	37
Magnesium chloride	30

*Note: PAS-E is the generic nomenclature adopted by ICCBBA to describe platelet additive solutions in terms of their active ingredients: citrate, phosphate, acetate, magnesium and potassium. This nomenclature allows for solutions with the same active ingredients from different commercial sources to be coded in the same manner. SSP+ is one of the PAS-E platelet additive solutions.