Additives and anticoagulants
Anticoagulant for whole blood collections
CPD (citrate phosphate dextrose)
Macopharma
66.5 mL of CPD anticoagulant is used per pack of whole blood.
| Constituents | g/L | Total per pack (g) |
|---|---|---|
| Sodium citrate dihydrate | 26.3 | 1.75 |
| Citric acid monohydrate | 3.27 | 0.22 |
| Monobasic sodium phosphate dihydrate | 2.51 | 0.17 |
| Dextrose monohydrate | 25.5 | 1.70 |
Anticoagulant for plasmapheresis collections
4% sodium citrate
Haemonetics Corporation
250mL mixed ~ 1:16 with whole blood
| Constituents | g/L |
|---|---|
| Sodium citrate dihydrate | 40 |
Anticoagulant for plateletpheresis collections
ACD-A (acid citrate dextrose)
Terumo BCT
750mL mixed ~ 1:11 with whole blood
| Constituents | g/L |
|---|---|
| Dextrose monhydrate | 24.5 |
| Sodium citrate dihydrate | 22.0 |
| Citric acid monohydrate | 8.0 |
Red cell additive solution
SAGM (saline adenine glucose mannitol)
Macopharma
105 mL of SAGM is used as the additive solution for resuspension of standard red cell components.
| Constituents | g/L | Total per pack (g) |
|---|---|---|
| Sodium chloride | 8.77 | 0.92 |
| Adenine | 0.169 | 0.02 |
| Dextrose monohydrate | 9.0 | 0.95 |
| Mannitol | 5.25 | 0.55 |
Washed red cells additive solution
SAGM (saline adenine glucose mannitol)
Macopharma
250 mL of SAGM is for washing of red cells. 100 mL of SAGM is used as the additive solution for resuspension of washed red cells, red cells for IUT and thawed frozen red cells.
| Constituents | g/L | Total per pack (g) |
|---|---|---|
| Sodium chloride | 8.77 | 0.877 |
| Adenine | 0.169 | 0.03 |
| Dextrose monohydrate | 8.18 | 0.818 |
| Mannitol | 5.25 | 0.525 |
Platelet additive solution (PAS)
SSP+*
Macopharma
The volume of platelet additive solution contained in each unit of Platelets Pooled in SSP+ is approximately 70% of total component volume.
The volume of platelet additive solution contained in each unit of Platelets Apheresis in PAS-E Leucocyte Depleted is approximately 70% of the total component volume.
| Constituents | mg/100mL |
|---|---|
| Sodium chloride | 405 |
| Sodium acetate trihydrate | 442 |
| Sodium citrate dihydrate | 318 |
| Sodium dihydrogenophosphate | 105 |
| Di-sodium hydrogenophosphate | 305 |
| Potassium chloride | 37 |
| Magnesium chloride | 30 |
*Note: PAS-E is the generic nomenclature adopted by ICCBBA to describe platelet additive solutions in terms of their active ingredients: citrate, phosphate, acetate, magnesium and potassium. This nomenclature allows for solutions with the same active ingredients from different commercial sources to be coded in the same manner. SSP+ is one of the PAS-E platelet additive solutions.
Updated March 2025
Related resources
Blood Component Information: An Extension of Blood Component Labels
Guide
Information Sheet
