Platelet and neutrophil testing
Labelling requirements for all tests
Request forms and sample labels must be completed accurately and have legible handwriting. Alternatively, the request form can be filled out online or a hospital label can be used.
Ensure the request form contains a minimum of three forms of unique identifiers (e.g., full name, date of birth, UR/MRN).
Ensure that all tubes, at a minimum, are clearly labelled with the below information and the information on the form matches that on the sample tube(s):
- patient’s full name (family name and given name/s)
- date of birth, and
- date of collection, as indicated on the request form.
- Autoantibodies for immune thrombocytopenia
Description Detection of autoantibodies against platelets, which can lead to immune thrombocytopenia Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02189 - Platelet Investigation Test performed by QTIS - Queensland
VTIS - Victoria
- Post-transfusion purpura (PTP)
Description Identifies antibodies against platelet-specific antigens that develop as a delayed blood transfusion reaction, leading to a sudden drop in platelet count Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02189 - Platelet Investigation Test performed by QTIS - Queensland
VTIS - Victoria
- Platelet glycoprotein expression
Description Measures the levels of glycoproteins IIb/IIIa and Ib/IX on the surface of platelets using flow cytometry. Aids in diagnosis of Glanzmann thrombasthenia and Bernard-Soulier syndrome, by identifying deficiencies in these glycoproteins. Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02189 - Platelet Investigation Test performed by QTIS - Queensland - Drug-induced immune thrombocytopenia (DITP)
Description Detects antibodies that react with platelets only in the presence of a specific drug, leading to thrombocytopenia. Suspected drug must be provided for the investigation. Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02189 - Platelet Investigation Test performed by QTIS - Queensland
VTIS - Victoria
- Fetal neonatal alloimmune thrombocytopenia (FNAIT)
Description Identifies maternal antibodies against fetal platelet antigens, which can cause thrombocytopenia in the fetus or newborn Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02191 - Fetal Neonatal Alloimmune Thrombocytopenia (FNAIT) Investigation Test performed by QTIS - Queensland
VTIS - Victoria
- Neonatal alloimmune neutropenia (NAIN)
Description Detects maternal antibodies against fetal neutrophil antigens, leading to neutropenia in the newborn.
Specimens should be collected on Wednesdays and sent directly to QTIS laboratory.
Testing is only conducted weekly on Thursday.
Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02300 - Neutrophil Investigation Test performed by QTIS - Queensland - Autoimmune neutropenia
Description Detects autoantibodies against neutrophils, which can lead to neutropenia.
Specimens requiring autologous testing should be collected on Wednesdays and sent directly to QTIS laboratory.
Testing is only conducted weekly on Thursday.
Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02300 - Neutrophil Investigation Test performed by QTIS - Queensland - Transfusion associated acute lung injury (TRALI)
Description Identifies HNA and/or HLA antibodies in the donor’s plasma that react with the recipient’s leucocytes, causing lung injury Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02300 - Neutrophil Investigation Test performed by QTIS - Queensland - Drug-induced immune neutropenia
Description Detects antibodies that react with neutrophils only in the presence of a specific drug, leading to neutropenia.
Suspected drug must be provided for the investigation.
Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02300 - Neutrophil Investigation Test performed by QTIS - Queensland - IgA antibodies
Description Detects antibodies to human IgA protein which may lead to adverse transfusion reactions Request form including sample requirements, storage/transport instructions, and turnaround times FRM-02299 - IgA Antibody Investigation Test performed by QTIS - Queensland