Cryoprecipitate is the part of plasma that contains a number of clotting proteins (factors) that help control bleeding. It's made by thawing fresh frozen plasma (FFP) between 1 and 6˚C and then collecting the cold-insoluble proteins (precipitate). This is then refrozen for storage and thawed again when someone needs it.
Blood clotting is really important when you’re bleeding. Cryoprecipitate has specific proteins involved in clotting, including:
- fibrinogen (essential for effective blood clotting)
- Factor VIII (the protein missing in patients with haemophilia A)
- Factor XIII (helps stabilise clots), and
- von Willebrand factor (helps the platelets stick together).