van der Wal Dianne E.

doctor dianne e van der wal

Dr Dianne E. van der Wal

Senior Research Fellow

Connect with Dr van der Wal Email LinkedIn Research Gate Pubmed

Dianne’s currently working on the platelet responses of apheresis platelet donors,and co-supervising a PhD student.

During her PhD (which she received from Utrecht University in the Netherlands), she demonstrated that novel death pathways were triggered in cold-stored platelets as a result of molecular changes in one of the platelet adhesion receptors.

Some patients suffering from bleeding disorder Immune thrombocytopenia (ITP) are unresponsive to current treatments. In her postdoc in Toronto, Canada, Dianne showed that certain antibodies induced removal of sialic acid leading to platelet clearance by liver macrophages. That means desialylation-inhibitors could possibly be used as a novel drug for ITP.

She also has experience teaching Human Pathology to 3rd year undergraduates as a senior tutor at Monash University, and teaching as a practical tutor at Utrecht University.

Awards
  • EHA-ISTH training fellowship (2018)
  • The Thrombosis and Haemostasis society of Australia and New Zealand travel award HAA (2017)
  • Control of Anticoagulation Travel Award and Young Investigator Award: XXIVth Congress of the International Society on Thrombosis and Haemostasis (2013)
  • Abstract Achievement Award: 54th Annual Meeting of American Society of Hematology (2012)
  • Young Investigator Award: XXIVth Congress of the International Society on Thrombosis and Haemostasis (2013)
  • Australian and New Zealand Society of Blood Transfusion research funds: The role of neuraminidases in platelet function in general and during storage (2017)
  • Personal (Post-doctoral) Fellowship from Canadian Blood Service, Canada: Unveiling the fundamental differences between anti-GPIbα and anti-GPIIbIIIa-antibody mediated thrombocytopenia: implications for IVIG and alternative therapies. (2011)
Leadership
  • Social media editor for Journal of Thrombosis and Haemostasis 
  • Reviewer for Platelets, EHA Hemashere, ISBT Science Series, Vox Sanguinis and ISBT Congress Abstracts
  • Chairperson for International Society on Thrombosis and Haemotosis, Melbourne (2019)
  • Chair of session at ISBT Congress, Nusa Dua (2015)

Key publications

Not all (N)SAID and done: Effects of nonsteroidal anti‐inflammatory drugs and paracetamol intake on platelets
Driver B, Marks DC, van der Wal DE.
2020
Res Pract Thromb Haemost
4: 36– 45
The role of neuraminidase 1 and 2 in Glycoprotein Ib alpha mediated alphaIIbbeta3 integrin activation
van der Wal DE, Davis AM, Mach M and Marks DC
2020
Haematologica
105: 1081-1094. ]
* Desialylation is a novel mechanism of Fc-independent platelet clearance and therapeutic target in immune thrombocytopenia.
Van der Wal DE, Li J, Zhu G, Xu M, Yougbare I, Ma L, Vadasz B,Grosovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai Z, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM and Ni H.
2015
Nat Comm
6:7737.
* Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα-14-3-3ζ]
van der Wal DE, Gitz E, Du VX, Lo KS, Koekman CA, Versteeg S and Akkerman. JWN
2012
Haematologica
97: 1514-22.
* Platelet apoptosis by cold-induced glycoprotein Ibα clustering
van der Wal DE, Du VX, Lo KSL, Rasmussen JT, Verhoef S and Akkerman JWN.
2010
J Thromb Haemost
8:2554-62.

* This research was completed prior to starting with Lifeblood