Doctor Dianne E. van der Wal

doctor dianne e van der wal

Dr Dianne E. van der Wal

Senior Research Fellow

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Dianne studies all factors influencing the quality of platelet components, including donor attributes, over the counter drugs. She also has interests in platelet glycans, microparticles and clearance mechanisms.

She enjoys mentoring of students and is active in science communication on Twitter. She is a member of the ANZSBT Education Standing Committee and social media/associate editor for journal of Thrombosis and Haemostasis. She previously showed carbohydrates are important for platelet clearance in bleeding disorder ITP, potentially leading to novel diagnosis or treatment approaches. During her Ph.D, she demonstrated novel platelet apoptosis pathways after cold-storage.

Awards
  • EHA-ISTH training fellowship (2018)
  • The Thrombosis and Haemostasis society of Australia and New Zealand travel award HAA (2017)
  • Control of Anticoagulation Travel Award and Young Investigator Award: XXIVth Congress of the International Society on Thrombosis and Haemostasis (2013)
  • Abstract Achievement Award: 54th Annual Meeting of American Society of Hematology (2012)
  • Young Investigator Award: XXIVth Congress of the International Society on Thrombosis and Haemostasis (2013)
  • Australian and New Zealand Society of Blood Transfusion research funds: The role of neuraminidases in platelet function in general and during storage (2017)
  • Personal (Post-doctoral) Fellowship from Canadian Blood Service, Canada: Unveiling the fundamental differences between anti-GPIbα and anti-GPIIbIIIa-antibody mediated thrombocytopenia: implications for IVIG and alternative therapies. (2011)
  • THANZ Congress Grant Blood (2021)
Leadership
  • Associate editor and social media editor for Journal of Thrombosis and Haemostasis
  • Reviewer for Journal of Thrombosis and Haemostasis, Blood
  • Reviewer for Platelets, EHA Hemashere, ISBT Science Series, Vox Sanguinis and ISBT Congress Abstracts
  • Chairperson for International Society on Thrombosis and Haemotosis, Melbourne (2019)
  • Chair of session at ISBT Congress, Nusa Dua (2015)
  • Member of the ANZSBT Education Standing Committee

Key publications

Not all (N)SAID and done: Effects of nonsteroidal anti‐inflammatory drugs and paracetamol intake on platelets
Driver B, Marks DC, van der Wal DE.
2020
Res Pract Thromb Haemost
4: 36– 45
The role of neuraminidase 1 and 2 in Glycoprotein Ib alpha mediated alphaIIbbeta3 integrin activation
van der Wal DE, Davis AM, Mach M and Marks DC
2020
Haematologica
105: 1081-1094. ]
* Desialylation is a novel mechanism of Fc-independent platelet clearance and therapeutic target in immune thrombocytopenia.
Van der Wal DE, Li J, Zhu G, Xu M, Yougbare I, Ma L, Vadasz B,Grosovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai Z, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM and Ni H.
2015
Nat Comm
6:7737.
* Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα-14-3-3ζ]
van der Wal DE, Gitz E, Du VX, Lo KS, Koekman CA, Versteeg S and Akkerman. JWN
2012
Haematologica
97: 1514-22.
* Platelet apoptosis by cold-induced glycoprotein Ibα clustering
van der Wal DE, Du VX, Lo KSL, Rasmussen JT, Verhoef S and Akkerman JWN.
2010
J Thromb Haemost
8:2554-62.

* This research was completed prior to starting with Lifeblood

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