Griffiths Rebecca

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Dr Rebecca Griffiths

Senior Research Fellow

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Becky’s research focus at Lifeblood is understanding red cell biology to make new and improved red cell reagents and therapeutics for patients with difficulty accessing compatible blood. 

Becky has a PhD in Biochemistry from Bristol University, and was previously part of the NIHR Blood and Transplant research team in the UK. There, she helped develop the first human clinical trial of cultured red blood cells for transfusion.

Awards
  • Wellcome Trust Pathfinder Award, co-applicant, 2016
  • Race and Sanger Award, British Blood Transfusion Society, 2012
  • Young Scientist Award, British Blood Transfusion Society, 2002
Leadership
  • Peer reviewer for Blood Journal

Key publications

* Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.
Thornton N, Karamatic Crew V, Tilley L, Green CA, Tay CL, Griffiths RE, Singleton BK, Spring F, Walser P, Alattar AG, Jones B, Laundy R, Storry JR, Möller M, Wall L, Charlewood R, Westhoff CM, Lomas-Francis C, Yahalom V, Feick U, Seltsam A, Mayer B, Olsso
2020
Nat Commun.
Jul 16;11(1):3569.
* Determinants of Zika virus host tropism uncovered by deep mutational scanning.
Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR,
2019
Nat Microbiol.
May;4(5):876-887.
* An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells.
Trakarnsanga K, Griffiths RE, Wilson MC, Blair A, Satchwell TJ, Meinders M, Cogan N, Kupzig S, Kurita R, Nakamura Y, Toye AM, Anstee DJ, Frayne J.
2017
Nat Commun.
Mar 14;8:14750.
* Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease.
Mankelow TJ*, Griffiths RE*, Trompeter S, Flatt JF, Cogan NM, Massey EJ, Anstee DJ.
2015
Blood
Oct 8;126(15):1831-4.
* Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis.
Griffiths RE, Kupzig S, Cogan N, Mankelow TJ, Betin VM, Trakarnsanga K, Massey EJ, Lane JD, Parsons SF, Anstee DJ.
2012
Blood
Jun 28;119(26):6296-306.

* This research was completed prior to starting with Lifeblood